CCNF (Cyclin F) as a candidate gene for familial Hodgkin lymphoma: Additional evidence for the importance of mitotic checkpoint defects in tumorigenesis.
(2023) HemaSphere — Vol. 7, n° 12, p. e985 [1-5] (2023)
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- Authors
Boutry, Simon 
- Abstract
- (en) Hodgkin lymphoma (HL) is a relatively infrequent neoplasm (2.6 cases/100,000 individuals; https://www.lls.org/facts-and-statistics) of germinal center B cells, the etiology of which has a significant genetic component. Despite this, few studies have investigated genetic predisposition to familial HL (fHL); these have typically included very limited numbers of families and have not provided functional evidence supporting the role of the fHL-linked variants identified. Here, we performed whole exome sequencing (WES) on 22 HL patients from 11 families, followed by candidate gene prioritization and functional testing of variants in the CCNF (Cyclin F) gene, identified in 2 different families. Intriguingly, CCNF plays a role in DNA integrity and mitotic checkpoints, adding it to a growing list of genes in this category, potentially implicated in fHL. [...]
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Citations
Khoury, E., Maalouf, H., Mendola, A., Boutry, S., Camboni, A., D’Angiolella, V., Choquet, S., Landman-Parker, J., Besson, C., Poirel, H. A., & Limaye, N. (2023). CCNF (Cyclin F) as a candidate gene for familial Hodgkin lymphoma: Additional evidence for the importance of mitotic checkpoint defects in tumorigenesis. HemaSphere, 7(12), e985 [1-5]. https://doi.org/10.1097/HS9.0000000000000985 (Original work published 2023)