Chronic active multiple sclerosis (MS) lesions, seen on susceptibility-weighted (SWI) MRI as Paramagnetic Rim Lesions (PRL), are associated with increased clinical disability and axonal damage. Diffusion MRI (dMRI) can characterize in vivo PRL’s tissue damage, however the tissue microstructure specificity of dMRI models is limited. Here, we characterized PRL’s microstructure using 4 different models, including one novel dMRI model: Microstructure Fingerprinting (MF).