Central Vein Sign, Cortical Lesions, and Paramagnetic Rim Lesions for the Diagnostic and Prognostic Workup of Multiple Sclerosis
(2024) Neurology Neuroimmunology & Neuroinflammation — Vol. 11, n° 4 (2024) (2024) (2024)
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- (en) Background The diagnosis of multiple sclerosis (MS) can be challenging in clinical practice because MS presentation can be atypical and mimicked by other diseases. We evaluated the diagnostic performance, alone or in combination, of the central vein sign (CVS), paramagnetic rim lesion (PRL), and cortical lesion (CL), as well as their association with clinical outcomes. Methods In this multicenter observational study, we first conducted a cross-sectional analysis of the CVS (proportion of CVS-positive lesions or simplified determination of CVS in 3/6 lesions—Select3*/Select6*), PRL, and CL in MS and non-MS cases on 3T-MRI brain images, including 3D T2-FLAIR, T2*-echo-planar imaging magnitude and phase, double inversion recovery, and magnetization prepared rapid gradient echo image sequences. Then, we longitudinally analyzed the progression independent of relapse and MRI activity (PIRA) in MS cases over the 2 years after study entry. Receiver operating characteristic curves were used to test diagnostic performance and regression models to predict diagnosis and clinical outcomes.
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Borrelli, S., Martire, M. S., Stölting, A., Vanden Bulcke, C., Pedrini, E., Guisset, F., Bugli, C., Yildiz, H., Pothen, L., Elands, S., Martinelli, V., Smith, B., Jacobson, S., Du Pasquier, R. A., Van Pesch, V., Filippi, M., Reich, D. S., Absinta, M., & Maggi, P. (2024). Central Vein Sign, Cortical Lesions, and Paramagnetic Rim Lesions for the Diagnostic and Prognostic Workup of Multiple Sclerosis. Neurology Neuroimmunology & Neuroinflammation, 11(4 (2024) (2024)). https://doi.org/10.1212/nxi.0000000000200253 (Original work published 2024)