A brief period of postnatal visual deprivation permanently alters visual motion processing in early visual regions
(2021) NeuroCog — Location: Louvain-la-Neuve, Belgium (23.November.2021)
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- Abstract
- A transient absence of vision early in life permanently alters visual motion discrimination abilities in humans. However, how the absence of early visual experience shapes the development of the visual motion network remains unknown. To address this question, we used functional magnetic resonance imaging to characterize the brain response elicited by visual motion in adults born with dense bilateral cataract that were treated early in life. Our results suggest that early cataract-reversal patients (CAT) showed reduced recruitment of the early visual areas while processing motion information when compared to matched controls with typical visual development (CON). The reduced recruitment of the early visual cortex in CAT correlated with the duration of visual deprivation. No alterations were observed in the higher order visual motion area hMT+/V5. Psychophysiological interaction analyses demonstrated reduced interhemispheric connectivity in V1, and reduced connectivity between hMT+/V5 and V1 during visual motion processing. We further investigated the representation of individual motion directions in V1 and hMT+/V5 using multivariate pattern analyses (MVPA). We observed reduced motion direction information in V1, but not in hMT+/V5, in CAT when compared to CON. Furthermore, we observed selective alteration in the resting connectivity profile of V1 in CAT, but not in hMT+/V5. Altogether these results suggest that a brief and transient period of visual deprivation early in life has a region-specific impact on the visual motion network with V1 being permanently affected while hMT+/V5 shows some resilience to deprivation.
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Rezk, M., Mattioni, S., & Collignon, O. (2021). A brief period of postnatal visual deprivation permanently alters visual motion processing in early visual regions. NeuroCog, Louvain-la-Neuve, Belgium. https://hdl.handle.net/2078.5/213874