Alcoholic steatohepatitis: what's new in 2012?
(2012) Revue Médicale Suisse — Vol. 8, n° 352, p. 1646-1648 (2012)
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- Abstract
- Alcoholic liver disease is a spectrum of lesions, of which the most severe is alcoholic steatohepatitis (ASH). Recent European guidelines define alcoholic hepatitis as a clinical syndrome: the recent onset of jaundice and/or ascites in a patient with ongoing alcohol misuse. Next to infection, the most frequent aetiology is ASH, a histological diagnosis. In case of severe ASH, as defined by prognostic scores, a biopsy is needed to confirm the diagnosis. Non-severe forms of ASH may improve with interruption of alcohol abuse only; however survival of severe forms of ASH is improved by the association of corticosteroids and N-acetylcysteine. In case of uncontrolled infection, pentoxifylline may be administered. The Lille score, measured at the 7th day of corticosteroid therapy, measures response to therapy and guides the total duration of treatment.
- Affiliations
Hôpitaux Universitaires de Genève Service de gastro-entérologie et hépatologie
Citations
Goossens, N., Ditisheim, S., Lanthier, N., Spahr, L., & Hadengue, A. (2012). Alcoholic steatohepatitis: what’s new in 2012? Revue Médicale Suisse, 8(352), 1646-1648. https://hdl.handle.net/2078.5/206082 (Original work published 2012)