Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study.
(2013) Journal of Assisted Reproduction and Genetics — Vol. 30, p. 1289-1299 (2013)
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- Abstract
- This pilot study is the first to evaluate the risk of contamination of cryopreserved ovarian tissue from advanced-stage breast cancer patients by xenotransplantation for 6 months to immunodeficient mice, associated with more conventional screening methods. Our xenografting results are reassuring, but caution needs to be exercised, as MGB2 gene expression was detected in some cases. Larger numbers of ovarian tissue samples from patients with advanced-stage breast cancer are required to confirm our findings before ovarian tissue transplantation can be contemplated in these patients.
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Citations
Luyckx, V., Durant, J.-F., Camboni, A., Gilliaux, S., Andrade Amorim, C., Van Langendonckt, A., Irenge, L. M., Gala, J.-L., Donnez, J., & Dolmans, M.-M. (2013). Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study. Journal of Assisted Reproduction and Genetics, 30, 1289-1299. https://doi.org/10.1007/s10815-013-0065-3 (Original work published 2013)