Could trisialotransferrin be used as an additional biomarker to CDT in order to improve detection of chronic excessive alcohol intake?
(2014) Clinical Biochemistry — Vol. 47, n° 13-14, p. 1203-1208 (2014)
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- Objectives: Carbohydrate-deficient transferrin is a well-known biomarker widely used for detection of chronic excessive alcohol intake. However, under certain clinical conditions particularly frequently met amongst heavy drinkers (steatosis, fibrosis, cirrhosis…), it isn't a reliable biomarker. In this study, we tried to find additional biomarkers to CDT in order to improve detection of chronic excessive alcohol intake. Design and methods: We conducted a retrospective cohort study from December 2007 to December 2009. We focused mainly on three different groups: heavy drinking patients with active alcohol consumption (n = 243), cirrhotic patients (abstinent patients and non alcoholic cirrhosis, n = 44) and control group (n = 85). Results: In our study, CDT showed a poor sensitivity for diagnosis of heavy drinking patients (around 63%, and even lower) for cirrhotic patients and patients at advanced stage of fibrosis. Combination of CDT with trisialotransferrin enabled to improve significantly sensitivity and specificity (p-value AUC ROC < 0.001). When adding mean corpuscular volume and gamma-glutamyltransferase to this first combination, performances were even better (p-value < 0.001). This second cluster enabled to make a statistically significant difference between cirrhotic patients with active alcohol consumption compared to abstinent cirrhotic patients and to non alcoholic cirrhotic patients (p-value < 0.001). Conclusion: From our study, trisialotransferrin seems to be a useful additional biomarker to CDT in order to improve detection of chronic excessive alcohol intake.
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Tamigniau, A., Wallemacq, P., & Maisin, D. (2014). Could trisialotransferrin be used as an additional biomarker to CDT in order to improve detection of chronic excessive alcohol intake? Clinical Biochemistry, 47(13-14), 1203-1208. https://doi.org/10.1016/j.clinbiochem.2014.05.052 (Original work published 2014)