The hidden face of monocytes in particle-induced fibrosis and cancer
(2016) SEMINARS ISV — Location: Louvain-La-Neuve, Belgium (2.December.2016)
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- Abstract
- The respiratory toxicity of persistent inhaled particles such as silica, asbestos and carbon nanotubes, notably their capacity to induce fibrosis and malignant mesothelioma, remains a serious cause of concern for public health. Uncontrolled immune responses play a key role in tissue responses to particles. Our findings in animal model of lung fibrosis and peritoneal mesothelioma provide new insight on the early and sustained immunosuppressive microenvironment induced by toxic particles. We have recently characterized the molecular mechanisms by which monocytic immature myeloid cells (M-MDSC) are recruited, suppress T lymphocyte functions, and contribute to early fibrosis and mesothelioma development. These results contribute to open new horizons for discovering new key biomarkers and/or therapeutic targets for fibrosis and mesothelioma induced by inhaled particles.
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Huaux, F. (2016). The hidden face of monocytes in particle-induced fibrosis and cancer. SEMINARS ISV, Louvain-La-Neuve, Belgium. https://hdl.handle.net/2078.5/180564