High-Wattage E-Cigarettes Induce Tissue Hypoxia and Lower Airway Injury: A Randomized Clinical Trial.
(2018) American Journal of Respiratory and Critical Care Medicine — Vol. 198, n° 1, p. 123-126 (2018)
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- Authors
Chaumont, Martin 
- Abstract
- To the Editor:More than 5% of adults in the United States are current electroniccigarette (e-cigarette) users (1). The liquid vehicles that arevaporized in e-cigarettes are propylene glycol and glycerol. Regulare-cigarette users buy last-generation devices delivering a highenergy level to low coil resistance (subohm vaping). High-energysettings are used to increase heat and vapor production, to enhancethe throat and nicotine hits, while nicotine concentration in thee-liquid is reduced (2, 3). E-cigarettes with high output wattageincrease the quantity of e-liquid consumed per puff and producevolatile carbonyls by thermal degradation (3). Daily exposures tolarge amounts of high-temperature propylene glycol/glycerolaerosol may present a hazard to health. The preliminary resultspresented here are a part of a larger in-depth, placebo-controlled,randomized, crossover, and single-blinded study on thecardiorespiratory effects of e-cigarettes. We present here the mainhypothesis tested, namely, that acute vaporization of a propyleneglycol and glycerol mix (50:50), under intense use conditions, alterslung and skin microvascular functions via an oxidative stresspathway (ClinicalTrials.gov identifier: NCT03036644) [...]
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Citations
Chaumont, M., Bernard, A., Pochet, S., Mélot, C., El Khattabi, C., Reye, F., Boudjeltia, K. Z., Van Antwerpen, P., Delporte, C., & van de Borne, P. (2018). High-Wattage E-Cigarettes Induce Tissue Hypoxia and Lower Airway Injury: A Randomized Clinical Trial. American Journal of Respiratory and Critical Care Medicine, 198(1), 123-126. https://doi.org/10.1164/rccm.201711-2198LE (Original work published 2018)