Liver progenitor cell expansion in the injured mouse liver: Do Kupffer cells play a role?
(2010) XXIIth Belgian Week of Gastroenterology — Location: Antwerp, Belgium (4.March.2010)
Files
No attached file found for this publication.
Details
- Authors
- Abstract
- In chronic injury, liver progenitor cells (LPCs) proliferate before undergoing differentiation. Previous work from our lab suggested that extracellular matrix (ECM) deposition and activation of mesenchymal cells during this process condition LPCs expansion and differentiation. Kupffer cells (KC) are active modulators of hepatic fibrosis. We therefore aimed at analysing the role of KC in a model of induced LPC proliferation. Our data to date demonstrate that, in the CDE model, beside ECM deposition and activation of matrix producing cells, massive activation of KC is also a significant component of the micro-environmental changes preceding LPCs expansion. Depletion of KC in the early phase is associated with a decreased expression of pro-fibrotic genes such as TGF- and collagen I. Multiple clodronate injections are currently investigated in order to obtain long lasting KC depletion to analyse the influence of KC on LPC reaction.
- Affiliations
Citations
Van Hul, N., Lanthier, N., & Leclercq, I. (2010). Liver progenitor cell expansion in the injured mouse liver: Do Kupffer cells play a role? Belgian Week of Gastroenterology Abstract Book, p. 12. https://hdl.handle.net/2078.5/161131