Can peripheral markers indicate neuroinflammation ?
(2011) 13th ESBRA Congress — Location: Vienna (A) (4.September.2011)
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- Authors
- Abstract
- There is increasing evidence that indicates that there is an association between the circulating concentrations of low-grade chronic inflammatory markers with cognitive symptoms of depression, Parkinson's and Alzheimer's disease. However, there have been no studies as to whether such changes occur in chronic alcohol abusers or intermittent alcohol users. Such alterations may be pertinent markers of alcohol-induced brain damage. In our recent studies, we have shown that alveolar macrophages isolated from ‘binge drinking’ rats are activated (increased IL-6 and TNFα production as well as inducible nitric oxide synthase activity), prior to and after lipopolysaccharide stimulation by comparison with control rats which were indicative of neuroinflammation in specific brain regions. Such changes were not apparent after the activation had been suppressed by administration of an NFkappaB inhibitor. These studies have been further extended in Belgian University students deemed to be ‘binge drinkers’ or not. General cognitive tests for personality, depression, anxiety, impulsivity and social cognition were assessed by validated questionnaires, and correlated with plasma cytokine content as well as the cytokine content in isolated blood monocytes before and after stimulation. The results of these studies indicate that combinations of various pro-inflammatory and anti-inflammatory cytokines may be pertinent markers of alcohol abuse and neuroinflammation in intermittent alcohol abusers.
- Affiliations
ULB - CHU Brugmann Labo de Psycho Médicale et Addictologie
Citations
Ward, R. J., De Witte, P., Lallemand, F., Noël, X., Campanella, S., & Verbanck, P. (2011). Can peripheral markers indicate neuroinflammation ? Alcohol and Alcoholism, 46(suppl.1), i13. https://doi.org/10.1093/alcalc/agr091 (Original work published 2011)