Matrix-enhanced secondary ion mass spectrometry: The Alchemist's solution?
(2006) Applied Surface Science — Vol. 252, n° 19, p. 6582-6587 (2006)
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- Because of the requirements of large molecule characterization and high-lateral resolution SIMS imaging, the possibility of improving molecular ion yields by the use of specific sample preparation procedures has recently generated a renewed interest in the static SIMS community. In comparison with polyatomic projectiles, however, signal enhancement by a matrix might appear to some as the alchemist's versus the scientist's solution to the current problems of organic SIMS. In this contribution, I would like to discuss critically the pros and cons of matrix-enhanced SIMS procedures, in the new framework that includes polyatomic ion bombardment. This discussion is based on a short review of the experimental and theoretical developments achieved in the last decade with respect to the three following approaches: (i) blending the analyte with a low-molecular weight organic matrix (MALDI-type preparation procedure); (ii) mixing alkali/noble metal salts with the analyte; (iii) evaporating a noble metal layer on the analyte sample surface (organic molecules, polymers). (c) 2006 Elsevier B.V. All rights reserved.
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Delcorte, A. (2006). Matrix-enhanced secondary ion mass spectrometry: The Alchemist’s solution? Applied Surface Science, 252(19), 6582-6587. https://doi.org/10.1016/j.apsusc.2006.02.076 (Original work published 2006)