Mapping of the Genes Encoding Tum- Transplantation Antigen-p91a, Antigen-p35b, and Antigen-p198
(1992) Immunogenetics —
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- Abstract
- Tum- comprises a class of genes, mutation of which in P815 tumor cells has led to the acquisition of new cytotoxic T cell-recognized epitopes. The cells carrying the mutant alleles have impaired tumorigenicity compared with their progenitors due to in vivo induction of a cytotoxic T-cell response specific for tum- antigens. Two tum- genes, P91A and P35B, were found to be single copy loci mapping to chromosomes 11 and 15 respectively. A third, P198, was found to map to chromosome 7 and to be a member of a small gene family with other members on chromosomes 13, 14, and 15. Multiple P198-related sequences were found in other mammalian species suggesting the P198 related gene family is a general feature of mammalian genomes.
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Dyson, PJ., De Smet, C., Knight, AM., Simonchazottes, D., Guénet, J.-L., & Boon, T. (1992). Mapping of the Genes Encoding Tum- Transplantation Antigen-p91a, Antigen-p35b, and Antigen-p198. Immunogenetics. https://doi.org/10.1007/BF00189894