Non-phase locked electroencephalogram (EEG) responses to CO2 laser skin stimulations may reflect central interactions between A partial partial differential- and C-fibre afferent volleys

Mouraux, André;Guerit, Jean-Michel;Plaghki, Léon
(2003) Clinical Neurophysiology — Vol. 114, n° 4, p. 710-722 (2003)

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  • Mouraux, Andréorcid-logoUCLouvain
    Author
  • Guerit, Jean-MichelUCLouvain
    Author
  • Plaghki, LéonUCLouvain
    Author
Abstract
OBJECTIVE: By co-activating A partial partial differential- and C-fibre nociceptors, intense CO2 laser heat stimuli produce a dual sensation, composed of first and second pain, but induce only a single A partial partial differential-fibre related late laser evoked potential (LEP). However, when avoiding concomitant activation of A partial partial differential-fibres, C-fibre related ultra-late LEPs are recorded. This poorly understood phenomenon was re-investigated using a method which, unlike time-domain averaging, reveals electroencephalogram (EEG) changes whether or not phase-locked to stimulus onset. METHODS: CO2 laser stimuli were applied to the dorsum of the hand. Reaction-time was used to discriminate between A partial partial differential- and C-fibre mediated detections. Analyses were performed using a method based on the time-frequency wavelet transform of EEG epochs. RESULTS: This study revealed: (1) a novel non-phase-locked component related to the activation of A partial partial differential-fibres occurring at similar latencies as the late LEP; and (2) a widespread post-stimulus event-related desynchronization (ERD) induced by both A partial partial differential- and C-fibres.CONCLUSIONS: A partial partial differential- and C-fibre related LEPs could be electrophysiological correlates of similar brain processes, which, when already engaged by A partial partial differential-fibres, cannot or do not need to be reactivated by the later arriving C-fibre afferent volley. A partial partial differential-fibre related ERD could reflect a transient change of state of brain structures generating these responses.
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Mouraux, A., Guerit, J.-M., & Plaghki, L. (2003). Non-phase locked electroencephalogram (EEG) responses to CO2 laser skin stimulations may reflect central interactions between A partial partial differential- and C-fibre afferent volleys. Clinical Neurophysiology, 114(4), 710-722. https://doi.org/10.1016/S1388-2457(03)00027-0 (Original work published 2003)