Biofunctionalized and self-supported polypyrrole frameworks as nanostructured ECM-like biointerfaces

Lefèvre, Damien;Louvegny, Juliette;Naudin, Mathieu;Ferain, Etienne;Demoustier, Sophie;et.al.
(2018) RSC Advances — Vol. 8, n° 41, p. 22932-22943 (2018)

Files

2018-LefevreetalRSCAdv20181.pdf
  • Open Access
  • Adobe PDF
  • 1.7 MB
Download

Details

Authors
Show more
Abstract
Hybrid nanobiointerfaces were designed as an original contribution to the challenge of synthesizing nanostructured biomaterials integrating a set of cell fate-determining cues, originally provided to cells by the extracellular matrix (ECM). The produced biointerfaces consist of a stiff framework of intersected polypyrrole (PPy) nanotubes supporting a soft multilayer composed of ECM-derived biomacromolecules: collagen (Col) and hyaluronic acid (HA). PPy frameworks with highly tunable characteristics were synthesized through chemical oxidative polymerization of pyrrole monomers, templated within tracketched polycarbonate (PC) membranes featuring a network of intersected nanopores. PPy interfaces with a porosity of 80%, composed of nanotubes with an average diameter ranging from 40 to 300 nm, intersecting at an angle of 90°, were shown to be self-supported. These rigid PPy nanostructured interfaces were functionalized with a self-assembling (HA/Col) multilayer deposited via a layerby...
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Lefèvre, D., Louvegny, J., Naudin, M., Ferain, E., Dupont, C., & Demoustier, S. (2018). Biofunctionalized and self-supported polypyrrole frameworks as nanostructured ECM-like biointerfaces. RSC Advances, 8(41), 22932-22943. https://doi.org/10.1039/c8ra00325d (Original work published 2018)