Co(ii) and Zn(ii) pyrazolyl-benzimidazole complexes with remarkable antibacterial activity
(2020) New Journal of Chemistry — Vol. 44, n° 6, p. 2210-2221 (2020)
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- Three mononuclear coordination complexes of 1-butyl-2-((5-methyl-1H-pyrazol-3-yl)methyl)-1H-benzimidazole (L), namely [CoL]Cl2 (C1), [Co2L2]Cl2·H2O (C2) and [Zn2L2]Cl2 (C3), have been synthesized and characterized spectroscopically. Their single-crystal X-ray diffraction analysis revealed that C1 and C2 display pseudopolymorphism. The presence of N–H⋯Cl and C–H⋯Cl hydrogen bonding in the crystal structure of C1 and C3 assists the formation of a 2D hydrogen bonded sheet and orthogonal packing [2D sheet + a pair of 1D chains], respectively, leading to supramolecular structures. A combination of N–H⋯Cl, C–H⋯Cl, O–H⋯Cl, and C–H⋯O interactions results however in a 2D corrugated hydrogen bonded sheet with inclusion of water molecules in C2. Hirshfeld surface analysis confirms that hydrogen bonding and π-stacking contacts stabilize the crystal structures. These metal complexes display good performance towards their antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. In particular a normalized minimum inhibitory concentration as low as 6.25 μg mL−1 for the bacterial strains was recorded for C2. Its structure–bioactivity correlation is discussed in detail.
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Chkirate, K., Karrouchi, K., Dege, N., Kheira Sebbar, N., Ejjoummany, A., Radi, S., Adarsh, N. N., Talbaoui, A., Ferbinteanu, M., Essassi, E. M., & Garcia, Y. (2020). Co(ii) and Zn(ii) pyrazolyl-benzimidazole complexes with remarkable antibacterial activity. New Journal of Chemistry, 44(6), 2210-2221. https://doi.org/10.1039/c9nj05913j (Original work published 2020)