The colonoscopic leakage model: a new model to study the intestinal wound healing at molecular level
(2020) Gut — Vol. 69, n° 12, p. 2071-2073 (2020)
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- Abstract
- (en) We describe a novel, fast-track, innovative intestinal wound healing model developed in mice called the ‘colonoscopic leakage model’. This model uses a colonoscopic biopsy grasper to make a controlled transmural perforation in the colon. Similar to other classic anastomotic leakage models, we observed about 50% incidence of peritonitis, although this model is less invasive, faster and avoids intestinal occlusion as well as massive bodyweight loss. Therefore, this preclinical model could be used to test potential therapeutic agents and to investigate the different molecular wound healing mechanisms. [...]
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Bachmann, R., Van Hul, M., Léonard, D., Delzenne, N., Kartheuser, A., & Cani, P. (2020). The colonoscopic leakage model: a new model to study the intestinal wound healing at molecular level. Gut, 69(12), 2071-2073. https://doi.org/10.1136/gutjnl-2020-321234 (Original work published 2020)