Utility of gonadotropin-releasing hormone agonists for fertility preservation in women receiving chemotherapy: pros and cons
(2020) Fertility and Sterility — Vol. 114, n° 4, p. 725-738 (2020)
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- (en) Chemotherapy-induced ovarian damage:apoptosis and/or in vitro activation?The term‘‘ovarian reserve’’is typically used to refer to the pop-ulation ofprimordial follicles (PMFs) .This population is very sensitive to cytotoxic drugs, especially alkylating agents (cyclo-phosphamide, busulfan, ifosfamide). Among them, cyclophos-phamide (CPA) is the alkylating agent that causes the mostdamage to oocytes and granulosa cells. Alkylating-like plat-inum complexes (such as cisplatin, anthracyclanes [includingdoxorubicin]) should also be considered as ovo-toxic drugs. [...]
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Dolmans, M.-M., Taylor, H. S., Rodriguez-Wallberg, K. A., Blumenfeld, Z., Lambertini, M., von Wolff, M., & Donnez, J. (2020). Utility of gonadotropin-releasing hormone agonists for fertility preservation in women receiving chemotherapy: pros and cons. Fertility and Sterility, 114(4), 725-738. https://doi.org/10.1016/j.fertnstert.2020.08.011 (Original work published 2020)