Heimiomycins A–C and Calamenens from the African Basidiomycete Heimiomyces sp.
(2020) Journal of Natural Products — Vol. 83, n° 8, p. 2501-2507 (2020)
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- Authors
Stadler, Marc 
- Abstract
- Three previously undescribed compounds named heimiomycin A−C (1−3), featuring a unique scaffold with calamenene connected to a hydroxystyryl-pyranone moiety, along with the new calamenene derivatives 4 and 5 and phenanthridine derivative (6) were obtained from a culture of a Heimiomyces sp. This is the first report of the occurrence of calamenene-type terpenoids in fungi. Compound 3 exhibited antimicrobial activity against Gram-positive bacteria and Mucor hiemalis. Compounds 1 and 3 displayed moderate cytotoxicity against KB 3.1 and L929 cell lines, respectively.
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Citations
Cheng, T., Chepkirui, C., Decock, C., Matasyoh, J. C., & Stadler, M. (2020). Heimiomycins A–C and Calamenens from the African Basidiomycete Heimiomyces sp. Journal of Natural Products, 83(8), 2501-2507. https://doi.org/10.1021/acs.jnatprod.0c00486 (Original work published 2020)