The oxysterome and its receptors as pharmacological targets in inflammatory diseases.
(2021) British Journal of Pharmacology — (2021)
Files
2021_Guillemot-Legris_Br_J_Pharmacol.pdf
Preprint
Open Access - Adobe PDF
- 1.51 MB
Details
- Authors
- Abstract
- Oxysterols have gained attention over the last decades and are now considered as full-fledged bioactive lipids. The study of their levels in several diseases, (e.g. atherosclerosis, obesity, neurodegenerative diseases) led to a better understanding of their involvement in (patho)physiological processes such as inflammation and immunity. For instance, the characterization of the cholesterol-7α,25-dihydroxycholesterol/GPR183 axis and its implication in immunity represents an important step in the oxysterome study. Besides this axis, others were identified as important in several inflammatory pathologies (such as colitis, lung inflammation, and atherosclerosis). However, the oxysterome is a complex system notably due to a redundancy of metabolic enzymes and a wide range of receptors. Indeed, deciphering oxysterol roles and identifying the potential receptor(s) involved in a given pathology remains challenging. Oxysterols properties are very diverse but most of them could be connected by a common component: inflammation. Here, we review the implication of oxysterol receptors in inflammatory diseases.
- Affiliations
Citations
Guillemot-Legris, O., & Muccioli, G. (2021). The oxysterome and its receptors as pharmacological targets in inflammatory diseases. British Journal of Pharmacology. Accepted/in-press. https://doi.org/10.1111/bph.15479 (Original work published 2021)