Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation
(2022) Trends in Molecular Medicine — Vol. 28, n° 3, p. 223-236 (2022)
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- Authors
Thibaut, Morgane 
- Abstract
- Bile acids are potent signaling molecules exerting diverse actions through bile 8 acid-activated receptors. Among them, the Farnesoid X receptor (FXR) and the 9 Takeda G protein-coupled receptor 5 (TGR5; GPBAR1), modulate the inflamma10 tion occurring in chronic/acute hepatitis, cholestasis, and inflammatory bowel 11 disease. A role for other bile acid-responsive receptors in this context is emerging. 12 This review aims to summarize recent advances on the immune-modulatory 13 actions of the bile acid-responsive receptors Shingosine-1-phosphate receptor 14 2 (S1PR2), pregnane X receptor (PXR), constitutive androstane receptor (CAR), 15 vitamin D receptor (VDR), and retinoic acid-related orphan receptor γt (RORγt). 16 How microbiota-derived bile acids contribute to intestinal and hepatic inflamma17 tion, potentially through these receptors, is also discussed. These concepts pave 18 the way to novel and innovative strategies aiming at modulating the gut microbiota 1920 to tackle inflammatory syndromes.
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Citations
Thibaut, M., & Bindels, L. (2022). Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation. Trends in Molecular Medicine, 28(3), 223-236. https://doi.org/10.1016/j.molmed.2021.12.006 (Original work published 2022)