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A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion
Akkermansia muciniphila is a gut commensal known to improve host metabolism. The outer membrane protein Amuc_1100 has been shown to partially replicate these beneficial effects. Here, Yoon et al. (2021) have identified a novel protein (P9) secreted by A. muciniphila that stimulates GLP-1 secretion, thereby adding new insight to the biomolecule era to treat metabolic diseases.
Cani, P., & Knauf, C. (2021). A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion. Cell Metabolism, 33(6), 1073-1075. https://doi.org/10.1016/j.cmet.2021.05.004 (Original work published 2021)