Force-induced unfolding of an antibiotic-bound outer-membrane protein.

Viljoen, Albertus;Dufrêne, Yves
(2022) Structure — Vol. 30, n° 3, p. 321-323 (2022)

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In this issue of Structure, Ritzmann et al. characterize the unfolding of the β-barrel assembly machinery component BamA with single-molecule force spectroscopy and reveal how an antibiotic changes BamA's mechanical properties and inhibits its activity. This work helps us understand the effects antibiotics have on Gram-negative outer membrane proteins.
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Viljoen, A., & Dufrêne, Y. (2022). Force-induced unfolding of an antibiotic-bound outer-membrane protein. Structure, 30(3), 321-323. https://doi.org/10.1016/j.str.2022.02.009 (Original work published 2022)