Combining Racetams with a Sweetener through Complexation
(2022) Crystal Growth & Design — Vol. 22, n° 5, p. 3016-3023 (2022)
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- Authors
Shemchuk, Oleksii 
- Abstract
- Combining active pharmaceutical ingredients (APIs) with sweeteners through crystal engineering is an attractive way to mask the bitter taste of drugs. However, traditional methods such as salt or cocrystal formation still suffer some major limitations. Herein, racetams, a series of normally bitter drugs, cannot be combined with the popular sweetener saccharin through either salt or cocrystal formation. We here, however, show how these compounds can be combined when zinc saccharinate is used rather than saccharin. The obtained complexes can either be identified starting from a binary target API/Zn saccharinate or a ternary API/ZnO/saccharin combination. This work opens up novel pathways to couple two compounds of interest through a crystal engineering approach.
- Affiliations
Citations
Leng, F., Robeyns, K., Leyssens, T., & Shemchuk, O. (2022). Combining Racetams with a Sweetener through Complexation. Crystal Growth & Design, 22(5), 3016-3023. https://doi.org/10.1021/acs.cgd.1c01462 (Original work published 2022)