A Greener Pathway to Enantiopurity: Mechanochemical Deracemization through Abrasive Grinding
(2023) Chemistry: A European Journal — (2023)
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- Abstract
- We report the first case of mechanochemical deracemization by using liquid-assisted abrasive grinding. The target molecule is a precursor of Paclobutrazol, an important fungicide and plant growth inhibitor. Using mechanochemical deracemization, we are even able to transform a 10 % ee scalemic mixture of this latter in an enantioenriched product of 97 % ee in a couple of hours. This is substantially shorter compared to solution-based deracemization methodologies. The present paper thus introduces an efficient and greener process to enantiopure material.
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Lopes, C., Cartigny, Y., Brandel, C., Dupray, V., Body, C., Shemchuk, O., & Leyssens, T. (2023). A Greener Pathway to Enantiopurity: Mechanochemical Deracemization through Abrasive Grinding. Chemistry: A European Journal. Published. https://doi.org/10.1002/chem.202300585 (Original work published 2023)