Microbiota-derived metabolites as drivers of gut-brain communication.
(2022) Gut microbes — Vol. 14, n° 1, p. 2102878 [1-33] (2022)
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- Authors
Ahmed, Hany 
- Abstract
- Alterations in the gut microbiota composition have been associated with a range of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes transform and metabolize dietary- and host-derived molecules generating a diverse group of metabolites with local and systemic effects. The bi-directional communication between brain and the microbes residing in the gut, the so-called gut-brain axis, consists of a network of immunological, neuronal, and endocrine signaling pathways. Although the full variety of mechanisms of the gut-brain crosstalk is yet to be established, the existing data demonstrates that a single metabolite or its derivatives are likely among the key inductors within the gut-brain axis communication. However, more research is needed to understand the molecular mechanisms underlying how gut microbiota associated metabolites alter brain functions, and to examine if different interventional approaches targeting the gut microbiota could be used in prevention and treatment of neurological disorders, as reviewed herein.
- Affiliations
Citations
Ahmed, H., Leyrolle, Q., Koistinen, V., Kärkkäinen, O., Layé, S., Delzenne, N., & Hanhineva, K. (2022). Microbiota-derived metabolites as drivers of gut-brain communication. Gut microbes, 14(1), 2102878 [1-33]. https://doi.org/10.1080/19490976.2022.2102878 (Original work published 2022)