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Photo-induced telomeric DNA damage in human cancer cells

Weynand, Justin;Episkopou, Charikleia;Le Berre, Gabriel;Gillard, Martin;Elias, Benjamin;et.al.
(2022) RSC Chemical Biology — Vol. 3, n° 12, p. 1375-1379 (2022)

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Authors
  • Weynand, JustinUCLouvain
    Author
  • Episkopou, CharikleiaUCLouvain
    Author
  • Le Berre, GabrielUCLouvain
    Author
  • Gillard, Martinorcid-logoUCLouvain
    Author
  • Dejeu, JérômeUCLouvain
    Author
  • Decottignies, Anabelleorcid-logoUCLouvain
    Author
  • Defrancq, EricUCLouvain
    Author
  • Elias, Benjaminorcid-logoUCLouvain
    Author
  • et. al.
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Abstract
Herein we report on the study of novel dinuclear ruthenium(II) complexes designed to target and to photo-react with G-quadruplex telomeric DNA. Upon irradiation, complexes efficiently generate guanine radical cation sites as photo-oxidation products. The compounds also display efficient cell penetration with localization to the nucleus and show strong photocytotoxicity toward osteosarcoma cells. Thanks to a microscopic-based telomere dysfunction assay, which allows the direct visualization of DNA damage in cells, we brought the first evidence of forming photo-oxidative damage at telomeres in cellulo. This emphasizes interesting prospects for the development of future cancer phototherapies.
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Weynand, J., Episkopou, C., Le Berre, G., Gillard, M., Dejeu, J., Decottignies, A., Defrancq, E., Elias, B., & et al. (2022). Photo-induced telomeric DNA damage in human cancer cells. RSC Chemical Biology, 3(12), 1375-1379. https://doi.org/10.1039/D2CB00192F (Original work published 2022)