Predictors of osteo-articular infection in bacteremia in a tertiary center between 2017 and 2022.
(2026) Journal of bone and joint infection — Vol. 11, n° 1, p. 5-13 (2026)
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Castanares Zapatero, Diego 
- Abstract
- INTRODUCTION: Among bloodstream infections, Staphylococcus aureus bacteremia (SAB) is associated with a particularly high mortality rate, which may be higher in patients with undiagnosed metastatic infections. The primary objective of the present study was to identify risk factors for osteo-articular infection (OAI) in patients with active SAB. METHODS: A retrospective study was conducted in a single-center tertiary-care hospital in Brussels, Belgium. Data were collected on patients diagnosed with SAB between 2017 and 2022. RESULTS: Among the 489 consecutive patients with SAB included in this study, 141 (28.8 %) had a concomitant osteo-articular infection (OAI), accounting for nearly one in three patients. These infections included osteomyelitis (12.7 %), native joint septic arthritis (NJSA) (8.8 %), spondylodiscitis (8.4 %), and prosthetic joint infection (PJI) (3.9 %). Univariate and multivariate analyses were performed to identify risk factors associated with OAI. The duration of bacteremia (OR (odds ratio): 1.27, 95 %, CI (confidence interval): 1.14-1.42, p<0.001 ) and community-acquired bacteremia (OR: 3.23, 95 % CI: 1.85-5.88, p<0.001 ) were associated with the occurrence of OAI. The presence of active cancer (OR: 0.14, 95 % CI: 0.06-0.31, p<0.001 ) and intensive care unit (ICU) admissions for SAB (OR: 0.31, 95 % CI: 0.17-0.56, p<0.001 ) were associated with a lower likelihood of OAI. CONCLUSION: In this cohort, OAI was very frequent during SAB and occurred in 28.8 %, particularly in patients with community-acquired SAB (CA-SAB) or those with a longer duration of bacteremia. These findings highlight the importance of a comprehensive diagnostic evaluation for both primary and secondary infection foci, such as OAI, in the setting of SAB.
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Citations
Vandenbergen, L., Castanares Zapatero, D., Briol, S., Verroken, A., Belkhir, L., Cornu, O., & Yombi, J. C. (2026). Predictors of osteo-articular infection in bacteremia in a tertiary center between 2017 and 2022. Journal of bone and joint infection, 11(1), 5-13. https://doi.org/10.5194/jbji-11-5-2026 (Original work published 2026)