Effets de l’âge et du genre sur la perfusion cérébrale régionale étudiée par deux méthodes d’analyse statistique voxel-par-voxel
(2009) Medecine Nucleaire : imagerie fonctionelle et metabolique — Vol. 33, n° 10, p. 625-631 (2009)
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- Fully automated analysis programs have been applied more and more to aid for the reading of regional cerebral blood flow SPECT study. They are increasingly based on the comparison of the patient study with a normal database. In this study, we evaluate the ability of Three-Dimensional Stereotactic Surface Projection (3D-SSP) to isolate effects of age and gender in a previously Studied normal population. The results were also compared with those obtained using Statistical Parametric Mapping (SPM99). Methods. - Eighty-nine Te-99m-ECD-SPFCT studies performed in carefully screened healthy volunteers (46 females, 43 males; age 20-81 years) were analysed using 3D-SSP. A multivariate analysis based on the general linear model was performed with regions as intrasubject factor, gender as intersubject factor and age as covariate. Results. - Both age and gender had a significant interaction effect with regional tracer uptake. An age-related decline (p < 0.001) was found in the anterior cingulate gyrus, left frontal association cortex and left insula. Bilateral occipital association and left primary visual cortical uptake showed a significant relative increase with age (p < 0.001). Concerning the gender effect, women showed higher uptake (p < 0.01) in the parietal and right sensorimotor cortices. An age by gender interaction (p < 0.01) was only found in the left medial frontal cortex. The results were consistent with those obtained with SPM99. Conclusion. - 3D-SSP analysis of normal rCBF variability is consistent with the literature and other automated voxel-based techniques, which highlight the effects of both age and gender. (C) 2009 Elsevier Masson SAS. All rights reserved.
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Pirson, A.-S., Van Laere, K., George, J., Jamart, J., Krug, B., D’Asseler, Y., Minoshima, S., & Vander Borght, T. (2009). Effets de l’âge et du genre sur la perfusion cérébrale régionale étudiée par deux méthodes d’analyse statistique voxel-par-voxel. Medecine Nucleaire : imagerie fonctionelle et metabolique, 33(10), 625-631. https://doi.org/10.1016/j.mednuc.2009.07.009 (Original work published 2009)