Conversion of t11t13 CLA into c9t11 CLA in Caco-2 Cells and Inhibition by Sterculic Oil

Schneider, Anne-Catherine;Beguin, Pauline;Bourez, Sophie;Perfield II, James W.;Larondelle, Yvan;et.al.
(2012) PLoS One — Vol. 7, n° 3, p. e32824 (2012)

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Authors
  • Schneider, Anne-CatherineUCLouvain
    Author
  • Beguin, PaulineUCLouvain
    Author
  • Bourez, SophieUCLouvain
    Author
  • Perfield II, James W.University of Missouri
    Author
  • Mignolet, EricUCLouvain
    Author
  • Debier, CathyUCLouvain
    Author
  • Schneider, Yves-JacquesUCLouvain
    Author
  • Larondelle, YvanUCLouvain
    Author
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Abstract
Background : Conjugated linoleic acids (CLA), and principally c9t11 CLA, are suspected to have numerous preventive properties regarding non-infectious pathologies such as inflammatory diseases, atherosclerosis and several types of cancer. C9t11 CLA is produced in the rumen during biohydrogenation of linoleic acid, but can also be synthesized in mammalian tissues from trans-vaccenic acid (C18:1 t11) through the action of delta-9 desaturase (D9D). For several years, it is also known that c9t11 CLA can be synthesized from conjugated linolenic acids (CLnA), i.e. c9t11c13 CLnA and c9t11t13 CLnA. This study aimed at investigating to which extent and by which route c9t11 CLA can be produced from another isomer of CLA, the t11t13 CLA that is structurally very similar to c9t11t13 CLnA, in Caco-2 cells.
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Schneider, A.-C., Beguin, P., Bourez, S., Perfield II, J. W., Mignolet, E., Debier, C., Schneider, Y.-J., & Larondelle, Y. (2012). Conversion of t11t13 CLA into c9t11 CLA in Caco-2 Cells and Inhibition by Sterculic Oil. PLoS One, 7(3), e32824. https://doi.org/10.1371/journal.pone.0032824 (Original work published 2012)