Designing the selenium and bladder cancer trial (SELEBLAT), a phase lll randomized chemoprevention study with selenium on recurrence of bladder cancer in Belgium.
(2012) BMC Urology — Vol. 12, p. 8 (2012)
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- [Background] : In Belgium, bladder cancer is the fifth most common cancer in males (5.2%) and the sixth most frequent cause of death from cancer in males (3.8%). Previous epidemiological studies have consistently reported that selenium concentrations were inversely associated with the risk of bladder cancer. This suggests that selenium may also be suitable for chemoprevention of recurrence. [Method] :The SELEBLAT study opened in September 2009 and is still recruiting all patients with non-invasive transitional cell carcinoma of the bladder on TURB operation in 15 Belgian hospitals. Recruitment progress can be monitored live at http://www.seleblat.org. webcite Patients are randomly assigned to selenium yeast (200 μg/day) supplementation for 3 years or matching placebo, in addition to standard care. The objective is to determine the effect of selenium on the recurrence of bladder cancer. Randomization is stratified by treatment centre. A computerized algorithm randomly assigns the patients to a treatment arm. All study personnel and participants are blinded to treatment assignment for the duration of the study.
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Goossens, M. E., Buntinx, F., Joniau, S., Ackaert, K., Ameye, F., Billiet, I., Braeckman, J., Breugelmans, A., Darras, J., Dilen, K., Goeman, L., Kellen, E., Tombal, B., Van Bruwaene, S., Van Cleyenbreuge, B., Van der Aa, F., Vekemans, K., Van Poppel, H., & Zeegers, M. P. (2012). Designing the selenium and bladder cancer trial (SELEBLAT), a phase lll randomized chemoprevention study with selenium on recurrence of bladder cancer in Belgium. BMC Urology, 12, 8. https://doi.org/10.1186/1471-2490-12-8 (Original work published 2012)