DNMT3A gates IFN-induced MPN HSC exhaustion.

Constantinescu, Stefan;Vainchenker, William
(2024) Blood — Vol. 143, n° 24, p. 2445-2446 (2024)

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(en) In this issue of Blood, Usart et al1 provide strong experimental evidence that heterozygous and homozygous deletion of DNA methyltransferase 3 alpha (Dnmt3a) prevents JAK2V617F hematopoietic stem cell (HSC) exhaustion due to interferon alfa (IFN-α) in mouse models and human cells. This result explains the resistance to IFN-α therapy in JAK2V617F patients with DNMT3A-mutated hematopoietic cells. [...]
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Constantinescu, S., & Vainchenker, W. (2024). DNMT3A gates IFN-induced MPN HSC exhaustion. Blood, 143(24), 2445-2446. https://doi.org/10.1182/blood.2024024448 (Original work published 2024)