A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review.
(2022) Brachytherapy — Vol. 20, n° 2, p. 478-484 (2022)
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- PURPOSE: To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature. RESULTS (METHODS AND CASE DESCRIPTION): Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and one metachronous) underwent enucleation and perioperative brachytherapy to the tumor bed. With a minimum follow-up of 5 years, all three patients are in continuous complete remission with preserved kidney function. CONCLUSIONS: Although nephron sparing surgery aiming at tumor free-margins remains the gold standard for bilateral WT, tumor enucleation followed by brachytherapy may be considered in carefully selected patients at high risk for end-stage kidney failure. Given the rarity and complexity of the procedure, concentration of care of such patients is mandatory.
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Dávila Fajardo, R., Pieters, B. R., Wilde, J. C. H., Heij, H. A., Chrzan, R., Tytgat, G., Mavinkurve-Groothuis, A. M. C., Smets, A., Kroon, P. S., Van Damme, A., van de Ven, K. P., de Krijger, R. R., Lilien, M. R., Wijnen, M. H., van den Heuvel-Eibrink, M. M., & Janssens, G. O. (2022). A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review. Brachytherapy, 20(2), 478-484. https://doi.org/10.1016/j.brachy.2020.09.001 (Original work published 2022)