Chemotherapy with alkylating agents : Is follicle activation the only mechanism responsible for the loss of primordial follicles?
(2021) Fertility and sterility — Vol. 115, n° 5, p. 1166-1167 (2021)
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- (en) The detrimental effects of chemotherapeutic drugs on female reproduction have been known now for half a century. Still, understanding how chemotherapy affects gonadal function is a pressing issue. Indeed, one particular alkylating agent, cyclophosphamide (Cy), which induces DNA crosslinking and ultimately prevents DNA replication, is commonly used in cancer treatment. By the early 2000s, it had become increasingly evident that alkylating agents are responsible for ovarian damage and that exposing granulosa cells in growing follicles to these agents causes their apoptotic death and consequently, an abrupt decrease in antimüllerian hormone level. [...]
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Dolmans, M.-M., & Donnez, J. (2021). Chemotherapy with alkylating agents : Is follicle activation the only mechanism responsible for the loss of primordial follicles? Fertility and sterility, 115(5), 1166-1167. https://doi.org/10.1016/j.fertnstert.2021.03.015 (Original work published 2021)