An exceptional case of severe combined inherited thrombophilia successfully treated with rivaroxaban

Krumb, Evelien;Hermans, Cédric
(2020) Blood Coagulation and Fibrinolysis — Vol. 31, n° 4, p. 279-282 (2020)

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Abstract
We herein report the case of a young patient who presented with premature thromboembolic venous disease secondary to combined heterozygous G20210A prothrombin mutation, dual homozygosity for Factor V Leiden, and severe protein S deficiency. This association has never been reported to date and is likely to be exceptional, even in populations wherein these thrombophilia traits are more common. Long-term antithrombotic prophylaxis with rivaroxaban has proven successful in preventing clinical recurrence under prolonged treatment.
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Krumb, E., & Hermans, C. (2020). An exceptional case of severe combined inherited thrombophilia successfully treated with rivaroxaban. Blood Coagulation and Fibrinolysis, 31(4), 279-282. https://doi.org/10.1097/mbc.0000000000000904 (Original work published 2020)