Photoactivable nonsymmetrical bifunctional linkers for protein immobilization on attenuated total reflectance FTIR optical devices
(2013) European Journal of Organic Chemistry — Vol. 2013, n° 35, p. 7952-7959 (2013)
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- Authors
- Abstract
- The photosensitive 4-azido-2,3,5,6-tetrafluoro-1-benzoyl core has been connected to maleimide-, chloroacetyloxy-, or succinimidyl carbonate motifs through various spacers to furnish a series of bifunctional linkers. One linker (7a) has been used for the construction of a biosensor for β-lactam antibiotic detection by attenuated total reflectance FTIR (ATR-FTIR) spectroscopy. Linkers featuring a photosensitive aryl azide motif at one end and a function reactive toward nucleophiles at the other end are described. One linker is used for the construction of a biosensor for β-lactam antibiotic detection by attenuated total reflectance FTIR spectroscopy. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- Affiliations
ULB Center for Structural Biology and Bioinformatics Uliège Centre d'Ingénierie des Protéines (CIP)
Citations
Hammaecher, C., Joris, B., Goormaghtigh, E., & Marchand-Brynaert, J. (2013). Photoactivable nonsymmetrical bifunctional linkers for protein immobilization on attenuated total reflectance FTIR optical devices. European Journal of Organic Chemistry, 2013(35), 7952-7959. https://doi.org/10.1002/ejoc.201300939 (Original work published 2013)