Manifestations hémorragiques et élévation isolée du temps de céphaline activée chez l’adulte : à propos d’un cas clinique

Binet, Quentin;Lambert, Catherine;Sacre, Laurine;Eeckhoudt, Stéphane;Hermans, Cédric
(2017) Louvain médical — Vol. 136, n° 6, p. 327-332 (2018)

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(en) [Unexpected bleeding and isolated prolongation of activated partial thromboplastin time: a case report] The differential diagnosis of isolated prolongation of the activated partial thromboplastin time (aPTT) is vast. An infrequent but severe cause is acquired hemophilia A (AHA) which is due to the spontaneous formation of neutralizing antibodies against endogenous factor VIII. About half the cases are associated with pregnancy, post-partum, autoimmune diseases, malignancies, or adverse drug reactions. Symptoms include severe and unexpected bleeding that may prove lifethreatening. We report a case of AHA associated with bullous pemphigoid (BP), a chronic, autoimmune, subepidermal, blistering skin disease. AHA was completely cured and BP wellcontrolled with a short-term treatment consisting of methylprednisolone and rituximab.
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Binet, Q., Lambert, C., Sacre, L., Eeckhoudt, S., & Hermans, C. (2017). Manifestations hémorragiques et élévation isolée du temps de céphaline activée chez l’adulte : à propos d’un cas clinique. Louvain médical, 136(6), 327-332. https://hdl.handle.net/2078.5/56362 (Original work published 2018)