A clinically prognostic scoring system for patients receiving highly active antiretroviral therapy: Results from the EuroSIDA study

Lundgren, JD.;Mocroft, A.;Gatell, JM.;Ledergerber, B.;Phillips, Andrew;et.al.
(2002) 40th Interscience Conference on Antimicrobial Agents and Chemotherapy — Location: TORONTO(Canada) (17.September.2000)

Files

pdfdocument.pdf
  • Restricted Access
  • Adobe PDF
  • 1.74 MB
Request a copy

Details

Authors
  • Lundgren, JD.
    Author
  • Mocroft, A.
    Author
  • Gatell, JM.
    Author
  • Ledergerber, B.
    Author
  • Phillips, AndrewUCLouvain
    Author
Show more
Abstract
The risk of clinical progression for human immunodeficiency virus (HIV)-infected persons receiving treatment with highly active antiretroviral therapy (HAART) is poorly defined. From an inception cohort of 8457 HIV-infected persons, 2027 patients who started HAART during prospective follow-up were examined. Results were validated in another 2 groups of patients (n = 1946 and n = 1442). In total, 200 patients (9.9%) experienced clinical progression during 5177 person-years (incidence, 3.9/100 years). The most recently measured CD4 cell count, virus load, and hemoglobin level all were independently related to the risk of clinical progression, as was a diagnosis of severe AIDS before the start of HAART. On the basis of these findings, a scoring system was derived (range, 0-17). A single unit increase in the score was associated with a 38% increased risk of clinical progression (relative hazard, 1.38; 95% confidence interval, 1.33-1.43; P < .0001). The scoring system was validated with remarkably good agreement in the 2 other cohorts. This system can be used in patient and resource management.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Lundgren, JD., Mocroft, A., Gatell, JM., Ledergerber, B., Monforte, A., Hermans, P., Goebel, FD., Blaxhult, A., Kirk, O., & Phillips, A. (2002). A clinically prognostic scoring system for patients receiving highly active antiretroviral therapy: Results from the EuroSIDA study. The Journal of Infectious Diseases, 185(2), 178-187. https://doi.org/10.1086/338267 (Original work published 2002)