Exploring preservation modalities in a human pancreas model to investigate the effect on the islet isolation outcomes
(2024)
Files
Lastdancedef.pdf
Open Access - Adobe PDF
- 22.93 MB
Details
- Authors
- Supervisors
- Abstract
- Islet transplantation holds promise as a therapy for patients with type 1 diabetes. How-ever, the shortage of organs capable of yielding effective outcomes for diabetic recipients restricts this procedure to a limited number of patients. Hypothermic perfusion ma-chines emerge as an effective tool for broadening organ selection criteria, thanks to their ability to mitigate ischemia-reperfusion damage during the preservation phase. The objective of this thesis is to contribute fresh insights into the dynamic preservation of the pancreas for Langerhans islet isolation and to evaluate their impact on islet functionality. To achieve consistent results while circumventing inter-individual variability, we have developed a split pancreas model using human organs earmarked for research. This model facilitates the isolation of islets from the same organ, preserved using three distinct preservation technique.
- Affiliations
Citations
Buemi, A. (2024). Exploring preservation modalities in a human pancreas model to investigate the effect on the islet isolation outcomes. https://hdl.handle.net/2078.5/217140