Local heterochromatin enrichment promotes telomere clustering and PML nuclear body assembly at telomeres
(2026) Cell Reports — Vol. 45, n° 3, p. 117004 (2026)
Files
1-s2.0-S2211124726000823-main (1).pdf
Open Access - Adobe PDF
- 6.65 MB
Details
- Authors
Arnoult, Nausica 
- Abstract
- In brief Telomeres in ALT-positive cancers display reduced nucleosome density yet retain heterochromatin-associated factors. This study shows that telomeric heterochromatin drives telomere clustering and PML nuclear body assembly, while ATRX and DAXX suppress this process, establishing a role for telomeric chromatin in mediating ALT-associated subnuclear compartmentalization of telomeres.
- Affiliations
Citations
Taylor, E., Proctor, B., Vaurs, M., Wu, G., Mahieu, M., Shrestha, S., Morrison, D., Weatherly, L., Brelinsky, S., Raghunandan, M., Decottignies, A., & Arnoult, N. (2026). Local heterochromatin enrichment promotes telomere clustering and PML nuclear body assembly at telomeres. Cell Reports, 45(3), 117004. https://doi.org/10.1016/j.celrep.2026.117004 (Original work published 2026)