Expression of Mage Genes in Transitional-cell Carcinomas of the Urinary-bladder
(1995) International Journal of Cancer — Vol. 64, n° 1, p. 60-64 (1995)
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- Abstract
- Human genes MAGE-1 and MAGE-3 code for distinct antigens, which are recognized on melanoma cells by autologous cytolytic T lymphocytes (CTL). These antigens may constitute useful targets for anti-cancer immunotherapy, since no expression of MAGE genes has been observed in normal tissues other than testis. Out of 57 samples of primary transitional-cell carcinomas of the bladder, 12 (21%) expressed MAGE-1 and 20 (35%) expressed MAGE-3. All but one of the tumors expressing MAGE-1 also expressed MAGE-3. Genes MAGE-2 and MAGE-4, which are closely related to MAGE-1 and MAGE-3, were expressed by 30% and 33% of the tumors respectively. MAGE expression was more frequent in advanced tumor stages: 61% of the invasive tumors (stage greater than or equal to T2) were positive for expression of at least one of the four genes, whereas only 28% of the superficial tumors (stages Ta and T1) expressed these genes. (C) 1995 Wiley-Liss, Inc.
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Patard, JJ., Brasseur, F., Gildiez, S., Radvanyi, F., Marchand, M., François, P., Abiaad, AS., Van Cangh, P., Abbou, CC., Chopin, D., & Boon, T. (1995). Expression of Mage Genes in Transitional-cell Carcinomas of the Urinary-bladder. International Journal of Cancer, 64(1), 60-64. https://doi.org/10.1002/ijc.2910640112 (Original work published 1995)