Common metabolic alterations in cancer chemoresistance and radioresistance
(2020)
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- Abstract
- Cancer cells can acquire the ability to survive and grow despite anticancer therapies. In this context, mitochondria exert a central role by getting involved in metabolic adaptations, cell proliferation, death and signaling regulation. We therefore propose that mitochondrial alterations could play an important role in resistance to cancer treatments, and we focused on chemoresistance to cisplatin in ovarian cancer and radioresistance in head and neck cancer. Working in parallel with matched models sensitive and resistant cells, we found that cancer cells resistant to cisplatin or to radiotherapy rely on oxidative phosphorylation and display more abundant and more interconnected mitochondria than the corresponding parental cells. Altogether, our study identifies a metabolic profile associated with radioresistance and chemoresistance that could potentially be further exploited for anticancer therapy.
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Grasso, D. (2020). Common metabolic alterations in cancer chemoresistance and radioresistance. https://hdl.handle.net/2078.5/93362