MICROSTRUCTURE-INSPIRED MULTISCALE MODELING OF ARTERIAL TISSUE

Pétré, Maïté;Lauranne Maes;Hanon, Guillaume;Misael Dalbosco;Kerckhofs, Greet;et.al.
(2024) Conference of European Society of Biomechanics — Location: Edinbourgh, Scotland (30.June.2024)

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Abstract
Atherosclerosis is one of the most common causes of mortality, characterized by the accumulation of plaque and fatty deposits in the blood vessels, leading to occlusion. Although treatment options such as balloon angioplasty are available, their success is frequently hampered by an insufficient understanding of the intricate relationship between the tissue microstructure and mechanical behaviour of the vessel. Representative volume element (RVE) models offer a microstructurally informed approach and provide insights into how changes in microstructure affect the mechanical behavior of blood vessels, enabling a better understanding in disease progression. There are several RVEs for arterial tissue available. For example, in [1], a defined RVE incorporates two collagen fiber families that use embedded truss elements in a solid matrix to capture their orientation and dispersion. However, the elastin constituent is absent in this RVE as a separate phase, although it is abundant in the aorta. In this study, the model from [1] was expanded to include elastin constituents in the RVE model.
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Pétré, M., Lauranne Maes, Hanon, G., Delannay, L., Kerckhofs, G., & et al. (2024). MICROSTRUCTURE-INSPIRED MULTISCALE MODELING OF ARTERIAL TISSUE. Conference of European Society of Biomechanics, Edinbourgh, Scotland.