Dynamic enhancement of upper abdominal organs in normal volunteers with MRI and effects of contrast dose reduction

Coche, Emmanuel;Bret, P. M.;Reinhold, C.
(1999) Abdominal Imaging — Vol. 24, n° 6, p. 604-609 (1999)

Files

248185.pdf
  • Open Access
  • Adobe PDF
  • 170.59 KB
Download

Details

Authors
Abstract
To quantify enhancement parameters of the upper abdominal organs over time during magnetic resonance (MR) examinations and to evaluate the effect of a dose reduction of contrast medium on these parameters. Ten volunteers underwent two separate dynamic enhanced MR examinations with 0.1 and 0.075 mmol/kg of contrast medium, respectively. Breath-hold gradient-echo T1-weighted images were acquired every second for 118 s followed by delayed images. The percentages of enhancement, the time to maximum enhancement, and the area under the time-versus-enhancement curve were calculated for each organ. The mean times to maximum percentage of enhancement were less than 25 s for the pancreas, kidneys, and spleen and 50 s for the liver. The mean values of maximum percentage of enhancement for the standard/reduced doses were 72%/62% (pancreas), 165%/155% (kidneys), 114%/87% (spleen), and 67%/53% (liver). This difference was significant when liver enhancement was considered (p = 0.02). In addition, when the areas under the time-versus-enhancement curves were compared, the difference between the standard dose and reduced dose was significant for all organs tested (p < 0.05). Dynamic scanning of the upper abdomen should start early after contrast injection. Injection parameters should be standardized to capture arterial and venous enhancements in liver examinations. A 25% dose reduction did not significantly affect peak enhancement (except for the liver) but did significantly reduce overall enhancement.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Coche, E., Bret, P. M., & Reinhold, C. (1999). Dynamic enhancement of upper abdominal organs in normal volunteers with MRI and effects of contrast dose reduction. Abdominal Imaging, 24(6), 604-609. https://doi.org/10.1007/s002619900573 (Original work published 1999)