Enantio‐, Regio‐ and Chemoselective Copper‐Catalyzed 1,2‐Hydroborylation of Acylsilanes

Nagy, Audric;Collard, Laurent;Indukuri, Kiran;Leyssens, Tom;Riant, Olivier
(2019) Chemistry: A European Journal — (2019)

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Abstract
The enantioselective synthesis of synthetically significant (  -hydroxyallyl)silanes, (  -hydroxyaryl)silanes and (  hydroxyalkyl)silanes is reported. The present copper-catalysed 1,2hydroborylation of acylsilanes affords the aforementioned products in high yields and high enantiomeric excesses. This robust and scalable additive-free catalytic system relies on the use of low copper(II) acetate and diphosphine ligand loadings at room temperature in the presence of a commercially available and bench stable hydride source.
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Nagy, A., Collard, L., Indukuri, K., Leyssens, T., & Riant, O. (2019). Enantio‐, Regio‐ and Chemoselective Copper‐Catalyzed 1,2‐Hydroborylation of Acylsilanes. Chemistry: A European Journal. Accepted/in-press. https://doi.org/10.1002/chem.201901785 (Original work published 2019)