sIL7R concentrations in the serum reflect disease activity in the lupus kidney.

Lauwerys, Bernard;Husson, S Nieuwland;Maudoux, A L;Badot, Valérie;Houssiau, Frédéric
(2014) Lupus science & medicine — Vol. 1, n° 1 (2014)

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  • Lauwerys, BernardUCLouvain
    Author
  • Husson, S NieuwlandUCLouvain
    Author
  • Maudoux, A LUCLouvain
    Author
  • Badot, ValérieUCLouvain
    Author
  • Houssiau, FrédéricUCLouvain
    Author
Abstract
Evaluation of disease activity in systemic lupus erythematosus (SLE) nephritis is a challenge, and repeated renal biopsies are usually needed in order to confirm a suspicion of flare. In a previous cross-sectional study, we reported that serum soluble form of the interleukin-7 receptor (sIL7R) levels is strongly associated with nephritis in SLE patients. In the present study, we wanted to confirm the association between changes in serum sIL7R concentrations and renal disease activity in a large longitudinal cohort of SLE nephritis patients.
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Lauwerys, B., Husson, S. N., Maudoux, A. L., Badot, V., & Houssiau, F. (2014). sIL7R concentrations in the serum reflect disease activity in the lupus kidney. Lupus science & medicine, 1(1). https://doi.org/10.1136/lupus-2014-000036 (Original work published 2014)