Effects of granulocyte-colony-stimulating factor on progenitor cell mobilization and heart perfusion and function in normal mice.

Delgaudine, Marie;Lambermont, Bernard;Lancellotti, Patrizio;Roelants, Véronique;Beguin, Yves;et.al.
(2011) Cytotherapy — Vol. 13, n° 2, p. 237-247 (2011)

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Authors
  • Delgaudine, MarieUniversité de Liège
    Author
  • Lambermont, BernardUniversité de Liège
    Author
  • Lancellotti, PatrizioUniversité de Liège
    Author
  • Roelants, VéroniqueUCLouvain
    Author
  • Walrand, StéphanUCLouvain
    Author
  • Vanoverschelde, Jean-LouisUCLouvain
    Author
  • Beguin, YvesUniversité de Liège
    Author
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Abstract
Mobilization of stem cells and progenitor cells from the bone marrow (BM) into the peripheral blood (PB) by granulocyte-colony-stimulating factor (G-CSF) is being investigated for cardiac regeneration in ischemic heart disease. However, hematopoietic (HPC), mesenchymal (MPC) and endothelial (EPC) progenitor mobilization have not been optimized and the effect of G-CSF on myocardial perfusion and cardiac function in a normal heart has never been studied.
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Delgaudine, M., Lambermont, B., Lancellotti, P., Roelants, V., Walrand, S., Vanoverschelde, J.-L., Pierard, L., Gothot, A., & Beguin, Y. (2011). Effects of granulocyte-colony-stimulating factor on progenitor cell mobilization and heart perfusion and function in normal mice. Cytotherapy, 13(2), 237-247. https://doi.org/10.3109/14653249.2010.491820 (Original work published 2011)