ROR2 as a novel JAK1/2-associated receptor amplifying IFNγ signaling in colon adenocarcinoma

de Lhoneux, Juliette
(2026)

Files

Juliette de Lhoneux 2026.pdf
  • Restricted Access
  • Adobe PDF
  • 3.82 MB
Request a copy

Details

Authors
Supervisors
Lien, Wen-Hui  
 ;
Zhu, Jingjing  
Abstract
ROR2 is a Wnt co-receptor with established pro-tumorigenic roles in cancer cell invasion and metastasis. In colorectal adenocarcinoma, high ROR2 expression correlates with poor prognosis and advanced TNM stage. By studying its interactome with co-immunoprecipitation and mass spectrometry, we identified new binding partners, including JAK1 and JAK2, and showed that ROR2 amplifies IFNγ-JAK/STAT signaling, leading to increased expression of immune-related molecules such as PD-L1 and IDO1. These results suggest that, beyond its intrinsic effects on cancer cells, ROR2 may also reshape the tumor immune microenvironment.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

de Lhoneux, J. (2026). ROR2 as a novel JAK1/2-associated receptor amplifying IFNγ signaling in colon adenocarcinoma. https://hdl.handle.net/2078.5/276960