Glucose-induced O(2) consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic Beta-cells.
(2012) PLoS One — Vol. 7, n° 1, p. e29807 (2012)
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- Abstract
- Glucose increases the expression of glycolytic enzymes and other hypoxia-response genes in pancreatic beta-cells. Here, we tested whether this effect results from the activation of Hypoxia-Inducible-factors (HIF) 1 and 2 in a hypoxia-dependent manner.
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Bensellam, M., Duvillié, B., Rybachuk, G., Laybutt, D. R., Magnan, C., Guiot, Y., Pouysségur, J., & Jonas, J.-C. (2012). Glucose-induced O(2) consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic Beta-cells. PLoS One, 7(1), e29807. https://doi.org/10.1371/journal.pone.0029807 (Original work published 2012)