Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review.

Hellquist, Henrik;Skálová, Alena;Barnes, Leon;Cardesa, Antonio;Ferlito, Alfio;et.al.
(2016) Advances in Therapy : the international journal of drug, device and diagnostic research — Vol. 33, n° 3, p. 357-368 (2016)

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Authors
  • Hellquist, Henrik
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  • Skálová, Alena
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  • Barnes, Leon
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  • Cardesa, Antonio
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  • Hamoir, MarcUCLouvain
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  • Ferlito, Alfio
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Abstract
Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC-HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.
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Hellquist, H., Skálová, A., Barnes, L., Cardesa, A., Thompson, L. D. R., Triantafyllou, A., Williams, M. D., Devaney, K. O., Gnepp, D. R., Bishop, J. A., Wenig, B. M., Suárez, C., Rodrigo, J. P., Coca-Pelaz, A., Strojan, P., Shah, J. P., Hamoir, M., Bradley, P. J., Silver, C. E., et al. (2016). Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review. Advances in Therapy : the international journal of drug, device and diagnostic research, 33(3), 357-368. https://doi.org/10.1007/s12325-016-0298-5 (Original work published 2016)